Marque Bretagne


Hemarina is a biotechnology company with a strong R&D activity. Our teams have a unique know-how, based on fifteen years of fundamental research. The results of our research are the subject of numerous scientific articles published in leading journals.


Yu He, Qiang Chang, Feng Lu
Oxygen-releasing biomaterials for chronic wounds breathing: From theoretical mechanism to application prospect
Science Direct - 2023

Tae-Hee Kim, Se-Chang Kim, Won-Kyo Jung
Therapeutic effect of marine bioactive substances against periodontitis based on in vitro, in vivo, and clinical studies
Fisheries and Aquatic Sciences - 2023

Batool, F., Petit, C., Stutz, C., Özçelik, H., Gegout, P. Y., Benkirane-Jessel, N., Delpy, E., Zal, F., Leize-Zal, E., Huck, O.
M101, a therapeutic oxygen carrier derived from Arenicola marina, decreased Porphyromonas gingivalis-induced hypoxia and improved periodontal healing
J Periodontol. - 2022

Le Meur, Y., Delpy, E., Renard, F., Hauet, T., Badet, L., Rerolle, JP., Thierry, A., Büchler, M., Zal, F., Barrou, B.
HEMO2life® improves renal function independent of cold ischemia time in kidney recipients: A comparison with a large multicenter prospective cohort study
Artificial Organs. - 2021

Asong-Fontem, N., Panisello-Rosello, A., Lopez, A., Imai, K., Zal, F., Delpy, E., Rosello-Catafau, J., Adam, R.
A Novel Oxygen Carrier (M101) Attenuates Ischemia-Reperfusion Injuries during Static Cold Storage in Steatotic Livers
Int. J. Mol. Sci. - 2021

Le Daré, B., Ferron, PJ., Bellamri, N., Ribault, C., Delpy, E., Zal, F., Lagente, V., Gicquel, T.
A therapeutic oxygen carrier isolated from Arenicola marina decreases amanitin-induced hepatotoxicity
Toxicon. - 2021

Batool, F., Delpy, E., Zal, F., Leize-Zal, E., Huck, O.
Therapeutic potential of hemoglobin derived from the marine worm Arenicola marina (M101): a literature review of a breakthrough innovation
Mar Drugs.  - 2021

Özçelik, H., Batool, F., Corre, M., Garlaschelli, A., Conzatti, G., Stutz, C., Petit, C., Delpy, E., Zal, F., Leize-Zal, E., , Huck, O.
Characterization of a hyaluronic acid-based hydrogel containing an extracellularoxygen carrier (M101) for periodontitis treatment: an in vitro study
Int J Pharm.  - 2021

Ali, A., Watanabe, Y., Galasso, M., Watanabe, T., Chen, M., Fan, E., Brochard, L., Ramadan, K., Ribeiro, RVP., Stansfield, W., Gokhale, H., Gazzalle, A., Waddell, T., Liu, M., Keshavjee, S., Cypel, M.
An extracellular oxygen carrier during prolonged pulmonary preservation improves post-transplant lung function
J Heart Lung Transplant. - 2020

Batool, F., Stutz, C., Petit, C., Benkirane-Jessel, N., Delpy, E., Zal, F., Leize-Zal, E., Huck.
A therapeutic oxygen carrier isolated from Arenicola marina decreased P. gingivalis induced inflammation and tissue destruction.
Sci Rep. - 2020