Publications

Hemarina is a biotechnology company with a strong R&D activity. Our teams have a unique know-how, based on fifteen years of fundamental research. The results of our research are the subject of numerous scientific articles published in leading journals.

HEMARINA TECHNOLOGY

a. Mohamed Thaha, Kaarthikeyan Gurumoorthy
Evaluation of bioactive extracellular soluble Hemarina (M101) derived scaffolds for neovascularization in periodontal tissue regeneration
Journal of Oral Biology and Craniofacial Research - 2026
https://pdf.sciencedirectassets.com/282127/1-s2.0-S2212426825X00075/1-s2.0-S2212426826000035/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEMn%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJGMEQCICf1CJDpnV4OXGDOWJS%2FVRmRvcdRwm9bylDkZW5jTPvmAiBU%2FfgqerDrkYoj%2FPPLw1u%2FMbaq%2FkwBYHn9JDpSF%2FJZWSq7BQiS%2F%2F%2F%2F%2F%2F%2F%2F%2F%2F8BEAUaDDA1OTAwMzU0Njg2NSIMmer%2BZxiWf6qv%2BKkrKo8FGCpo%2BoflnDYMyHfSIkeiYF90VAliWrFeVxPBfAD%2FLMK7w%2Bq5lZNujpctuOtoqyv6we%2FLKuaS5M%2B52wjaZKSXZ925d7xnUZlSv5MJI5Kf5VbaRCmpPfSAIJDwxGOFPF794oVRtbf3KiVezGzuXuMuw3NqQWcM8hMRjTtQXNeSL8AczBhu0aASJcloP18Fijmfsp%2BDk7QFDS3nS%2FRLQSqWdaq19SfV9S3fLhiy3oSpkrECEvzKZAUsCLSYkrvTiqg4DVjE4mrIQJmSgoxc7cFG1%2B5pW%2FlFo%2FWcjraTyTCbY%2BbONWzL6O5QQl%2BIuW2Gw3oPa4YfnvlWb%2FGXoPZ%2F4V1w8CDuiPGYLJEE8NFLMfKCANAczEMQIziCY0uvcd7gctE75d1DE1HY3r6Fip7MUSl7WkaIDFCd7ehyHlaKaa5Lhb%2Bn4NVKq%2FgwupnqbvjLjZqrdOXETbr7WcNPqL%2Bz6t3DwpVSnwmaRCHYr%2F8qvKwplXbXLA9IWSUfvKjtb0IhgsLRjH%2BfmbNSKjaqZFozlkTvFAFfscjEO71La16jBjnZnT41K3e7uMsJSQww8aqGBXCzMrIgUY1iiHG0I79TqEXClj8211N8csRTqyY9SUoo8W8jPWmb%2BaJu7wzuoU9LzxltQ%2F%2FaIrvV8sbo636c5YpRcvcYUuGrYDGiWyKrmk7aZc9hAPyP%2BJpJGtNGX%2Bd4T9CuGsJcsdHX1rTxp4OaepSvLYrlZG6KjdOjyVYqPkTmEqQVWfXsiPawXO4ULlna%2FpngwlzNb%2FosJ1WAebsfios48%2FsE3Vs6Qp9tDPp2N%2FHxnL559RfEnZN7k5iB03ef7XO2cluF%2FBxX095rh4wm1nplglS1CBtm0MA0EiT1ynu20jDI37fLBjqyAQ%2B7kNVd2S3F60rn86cdzIgjgrS2coxxnF%2BZyDlwRGZLyxwVMGj2A7ngWueT15FSCTmLENQFWvcuNSuWmGCDi602WWDA7ie51NZpyP9G9bvQV%2B7UYtdsKf0SIS2NVxl7pgR6i1hNbGmZqyyyJTuJyruWjLSNvNSp14lnZ6S9U6njKGRoHDKKE4FMOnULj%2Fap41rvTd%2F6qnBPqw%2B4hKxpTQQGrIlrUAlkT%2Fvfa4U8gaKNKj0%3D&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20260119T095750Z&X-Amz-SignedHeaders=host&X-Amz-Expires=300&X-Amz-Credential=ASIAQ3PHCVTY6DR2BEE7%2F20260119%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Signature=99b349dfd7f0ce413c2590efae2bb68229012037653c86614e9a552a2791e192&hash=a102e7820a2d78aee77453647532162cf81f4113bb3d64c49ea7d030f3004165&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S2212426826000035&tid=spdf-5a85ae5a-35b1-4be9-98c2-b9acee8a53de&sid=7ce65f466088c54c7e481de8af64dc88f4e2gxrqb&type=client&tsoh=d3d3LnNjaWVuY2VkaXJlY3QuY29t&rh=d3d3LnNjaWVuY2VkaXJlY3QuY29t&ua=1c1d5c02525a55565407&rr=9c05785b8b4bc46a&cc=fr

Céline Stutz, Catherine Petit, Pierre-Yves Gegout, Camille Le Gall, Maria Permuy, Mónica López-Peña, Fernando Muñoz, Mario Garcia González, Bénédicte Puissant, Yves Renaudineau, Franck Zal, Elisabeth Leize-Zal, Olivier Huck
Evaluation of a Gel Loaded With M101 on Bone and Peri-Implantitis Healing: An Experimental In Vivo Study
Clinical Oral implants Research - 2025
https://doi.org/10.1111/clr.70022

Ugo Lancien, MD, MSc; Pierre-Joachim Mahe, MD; Aline Lepelletier, MD; Elisabeth Leize-Zal, MD; Laurent Lantieri MD, Phd; Pierre Perrot, MD, Phd;
Hydrogel Containing an Oxygen Carrier With Hemoglobin From the Marine Worm Arenicola Marina (M101) in the Management of Deep Burns
PRS Global Open 2025 13:e6930 - 2025
https://journals.lww.com/prsgo/fulltext/2025/07000/hydrogel_containing_an_oxygen_carrier_with.9.aspx

Ugo Lancien, MD, MSc; Pierre-Joachim Mahe, MD; Aline Lepelletier, MD; Elisabeth Leize-Zal, MD; Laurent Lantieri MD, Phd; Pierre Perrot, MD, Phd;
Hydrogel Containing Oxygen Carrier with Hemoglobin from the Marine Worm Arenicola Marina M101in Management of Deep Burns
PRS Global Open 2025 13:e6930 - 2025
https://journals.lww.com/prsgo/fulltext/2025/07000/hydrogel_containing_an_oxygen_carrier_with.9.aspx

Prof Laurent Lantieri, MD, Prof Bernard Cholley, MD, Prof Cedric Lemogne, MD, Romain Guillemain, MD, Prof Nicolas Ortonne, MD, Prof Philippe Grimbert, MD, et al
First human facial retransplantation: 30-month follow-up
The Lancet - 2020
https://www.thelancet.com/article/S0140673620324387/abstract

Prof Laurent Lantieri MD, Prof Bernard Cholley MD, Prof Cedric Lemogne MD, Romain Guillemain MD, Prof Nicolas Ortonne MD, Prof Philippe Grimbert MD et al.
First human facial retransplantation: 30-month follow-up
The Lancet, Volume 396, Issue 10264, 1758 - 1765-November 28, 2020 - 2020
https://www.thelancet.com/article/S0140673620324387/abstract

Tamer O.Awan, Martin Lhuaire, Laurent Lantieri; doi: 10.1097/GOX.0000000000006093.
Use of HEMHealing, an Oxygenating Dressing in the Treatment of a Full-thickness Burn on the Fingertips
last Reconstr Surg Glob Open . 2024 Aug 22; - 2024
https://journals.lww.com/prsgo/fulltext/2024/08000/use_of_hemhealing,_an_oxygenating_dressing_in_the.68.aspx

Tamer O.Awan, Martin Lhuaire, Laurent Lantieri
Use of HEMHealing, an Oxygenating Dressing in the Treatment of a Full-thickness Burn on the Fingertips
Plastic and Reconstructive Surgery Global Open - 2024
https://pubmed.ncbi.nlm.nih.gov/39175515/

Batool, F., Petit, C., Stutz, C., Özçelik, H., Gegout, P. Y., Benkirane-Jessel, N., Delpy, E., Zal, F., Leize-Zal, E., Huck, O.
M101, a therapeutic oxygen carrier derived from Arenicola marina, decreased Porphyromonas gingivalis-induced hypoxia and improved periodontal healing
J Periodontol. - 2022
https://pubmed.ncbi.nlm.nih.gov/35536914/

Yu He, Qiang Chang, Feng Lu
Oxygen-releasing biomaterials for chronic wounds breathing: From theoretical mechanism to application prospect
Science Direct - 2023
https://www.sciencedirect.com/science/article/pii/S2590006423001473