Publications

Hemarina is a biotechnology company with a strong R&D activity. Our teams have a unique know-how, based on fifteen years of fundamental research. The results of our research are the subject of numerous scientific articles published in leading journals.

HEMARINA TECHNOLOGY

Batool, F., Petit, C., Stutz, C., Özçelik, H., Gegout, P. Y., Benkirane-Jessel, N., Delpy, E., Zal, F., Leize-Zal, E., Huck, O.
M101, a therapeutic oxygen carrier derived from Arenicola marina, decreased Porphyromonas gingivalis-induced hypoxia and improved periodontal healing
J Periodontol. - 2022
https://pubmed.ncbi.nlm.nih.gov/35536914/

Le Meur, Y., Delpy, E., Renard, F., Hauet, T., Badet, L., Rerolle, JP., Thierry, A., Büchler, M., Zal, F., Barrou, B.
HEMO2life® improves renal function independent of cold ischemia time in kidney recipients: A comparison with a large multicenter prospective cohort study
Artificial Organs. - 2021
https://pubmed.ncbi.nlm.nih.gov/34951495/

Asong-Fontem, N., Panisello-Rosello, A., Lopez, A., Imai, K., Zal, F., Delpy, E., Rosello-Catafau, J., Adam, R.
A Novel Oxygen Carrier (M101) Attenuates Ischemia-Reperfusion Injuries during Static Cold Storage in Steatotic Livers
Int. J. Mol. Sci. - 2021
https://pubmed.ncbi.nlm.nih.gov/34445250/

Le Daré, B., Ferron, PJ., Bellamri, N., Ribault, C., Delpy, E., Zal, F., Lagente, V., Gicquel, T.
A therapeutic oxygen carrier isolated from Arenicola marina decreases amanitin-induced hepatotoxicity
Toxicon. - 2021
https://pubmed.ncbi.nlm.nih.gov/34274377/

Batool, F., Delpy, E., Zal, F., Leize-Zal, E., Huck, O.
Therapeutic potential of hemoglobin derived from the marine worm Arenicola marina (M101): a literature review of a breakthrough innovation
Mar Drugs. - 2021
https://pubmed.ncbi.nlm.nih.gov/34210070/

Özçelik, H., Batool, F., Corre, M., Garlaschelli, A., Conzatti, G., Stutz, C., Petit, C., Delpy, E., Zal, F., Leize-Zal, E., , Huck, O.
Characterization of a hyaluronic acid-based hydrogel containing an extracellularoxygen carrier (M101) for periodontitis treatment: an in vitro study
Int J Pharm. - 2021
https://pubmed.ncbi.nlm.nih.gov/34144138/

Ali, A., Watanabe, Y., Galasso, M., Watanabe, T., Chen, M., Fan, E., Brochard, L., Ramadan, K., Ribeiro, RVP., Stansfield, W., Gokhale, H., Gazzalle, A., Waddell, T., Liu, M., Keshavjee, S., Cypel, M.
An extracellular oxygen carrier during prolonged pulmonary preservation improves post-transplant lung function
J Heart Lung Transplant. - 2020
https://www.ncbi.nlm.nih.gov/pubmed/32334946

Batool, F., Stutz, C., Petit, C., Benkirane-Jessel, N., Delpy, E., Zal, F., Leize-Zal, E., Huck.
A therapeutic oxygen carrier isolated from Arenicola marina decreased P. gingivalis induced inflammation and tissue destruction.
Sci Rep. - 2020
https://pubmed.ncbi.nlm.nih.gov/32901057/

Le Meur, Y., Morelon, E., Essig, M., Thierry, A., Büchler, M., Drouin, S., Deruelle, C., Badet, L., Pesteil, F., Delpech, P-O., Boutin, J-M., Renard, F., Barrou, B.
First-in-human use of a marine oxygen carrier for organ preservation: a safety and proof-of-principle study.
Am J Transplant. - 2020
https://www.ncbi.nlm.nih.gov/pubmed/32012441

Alix, P., Val-Laillet, D., Turlin, B., Ben Mosbah, I., Burel, A., Bobillier, E., Bendavid, C., Delpy, E., Zal, F., Corlu, A., Boudjema, K.
Adding the oxygen carrier M101 to a cold-storage solution could be an alternative to HOPE for liver graft preservation.
JHEP Rep. - 2020
https://pubmed.ncbi.nlm.nih.gov/32695967/