The universal oxygen carrier
Currently, blood needs are greater than what blood banks can supply, and are constantly increasing due to longer life expectancy and medical advances. The lack of blood is thus responsible for many deaths. Worldwide, more than 112 million units (one unit equals 450 mL) of blood are collected each year1 but it would take 300 million units to cover the planet’s needs. In France alone, current blood needs require 10,000 donations per day2.
As such, HEMOXYCarrier® is a true innovation in the world of therapeutic oxygen carriers. Developed by Hemarina, this product is based on the high oxygen binding capacity of extracellular hemoglobin in marine worms. M101, the active ingredient of HEMOXYCarrier®, is a naturally extracellular hemoglobin perfected by 450 million years of evolution to circulate extracellularly in the vessels of Arenicola marina. It restores optimal oxygenation of the body without the side effects found in first generation products derived from intracellular hemoglobin from vertebrates (bovine or human hemoglobin).
These mammalian hemoglobins are chemically modified to function extracellularly, resulting in hypertensive effects by creating vasoconstriction of the vessels.
These changes are responsible for hypertensive effects by creating vasoconstriction of the vessels. This major deleterious effect has hindered the development of these first-generation products, and is not found with HEMOXYCarrier®3.
Indeed, M101, the active ingredient of HEMOXYCarrier®, is a naturally extracellular haemoglobin resulting from 450 million years of evolution which circulates extracellularly in the vessels of Arenicola marina.
Furthermore, HEMOXYCarrier® operates in a simple oxygen partial pressure gradient. No cofactor is required for oxygen fixation and release.
1. OMS – 10 facts about blood transfusions – June 2017
2. French Blood Establishment (Etablissement français du sang)
3. Tsai, A.G., Intaglietta, M., Sakai, H., Delpy, E., Drieu La Rochelle C., Rousselot M., Zal F. Microcirculation and NO-CO studies of a natural extracellular hemoglobin developed for an oxygen therapeutic carrier. Current Drug Discovery Technologies, 9(3):166-72. 2012 2012