The cell growth activator

HEMOXCell® will be to cell culture what Taq polymerase has been to molecular biology and the development of PCR technology. HEMOXCell® is a unique technological solution for cell culture and the bioproduction of recombinant proteins. It not only increases the growth rate and viability of cells in culture, but also increases the bioproduction yields of recombinant proteins or monoclonal antibodies without changing the culture conditions.

The HEMOXCell® innovationallows a physiological oxygen supply to the cells in culture. Oxygen is delivered according to their needs, while protecting them from the harmful effect of free radicals generated by cellular respiration, thanks to its intrinsic antioxidant activity. Simply added to the culture medium, HEMOXCell® can be used under standard culture conditions and offers a simple solution to difficult to grow cells or simple yield problems. The immediate benefit is to have a large quantity of recombinant cells and proteins available rapidly under optimal conditions, without generating oxidative stress such as that caused by bubbling solutions. We were able to demonstrate its use in the preservation of mesenchymal stem cells and their growth.

HEMOXCell® is available for sale. For more information on the terms and conditions of business, please send your request to hemoxcell@hemarina.com

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HEMOXCell® : Related Publications

Mouré, A., Bacou, E., Bosch, S., Jegou, D.,Salama, A., Riochet, D., Gauthier, O., Blancho, G., Soulillou, J.-P., Poncelet, D., Olmos, E., Bach, J.-M., Mosser, M. Extracellular hemoglobin combined with an O2‐generating material overcomes O2 limitation in the bioartificial pancreas. Biotechnology and Bioengineering, 116(5):1176-1189. - 2018 https://www.ncbi.nlm.nih.gov/pubmed/30593660

Le Pape, F., Richard, G., Porchet, E., Sourice, S., Dubrana, F., Férec, C., Polard, V., Pace, R., Weiss, P., Zal, F., Delépine, P., Leize, E. Adhesion, proliferation and osteogenic differentiation of human MSCs cultured under perfusion with a marine oxygen carrier on an allogenic bone substitute. Artificial Cells, Nanomedicine, and Biotechnology, 46(1):95-107. - 2018 https://www.ncbi.nlm.nih.gov/pubmed/28830269

Le Pape, F., Cosnuau-Kemmat, L., Richard, G., Dubrana, F., Férec, C., Zal, F., Leize, E., Delépine, P. HEMOXCell, a New Oxygen Carrier Usable as an Additive for Mesenchymal Stem Cell Culture in Platelet Lysate-Supplemented Media. Artificial Organs, 41(4):359-371. - 2017 https://www.ncbi.nlm.nih.gov/pubmed/28326561

Rodriguez-Brotons, A., Bietiger, W., Peronet, C., Langlois, A., Magisson, J., Mura, C., Sookhareea, C., Polard, V., Jeandidier, N., Zal, F., Pinget, M., Sigrist, S., Maillard, E. Comparison of Perfluorodecalin and HEMOXCell as Oxygen Carriers for Islet Oxygenation in an In Vitro Model of Encapsulation. Tissue Engineering Part A, 22(23-24):1327-1336 - 2016 https://www.ncbi.nlm.nih.gov/pubmed/27796164

Le Pape, F., Bossard, M., Dutheil, D., Rousselot, M., Polard, V., Férec, C., Leize, E., Delépine, P., Zal, F. Advancement in recombinant protein production using a marine oxygen carrier to enhance oxygen transfer in a CHO-S cell line. Artificial Cells, Nanomedicine, and Biotechnology, 43(3):186-195. - 2015 https://www.ncbi.nlm.nih.gov/pubmed/25961365