Publications

Hemarina is a biotechnology company with a strong R&D activity. Our teams have a unique know-how, based on fifteen years of fundamental research. The results of our research are the subject of numerous scientific articles published in leading journals.

HEMARINA TECHNOLOGY

Franck Zal, Leila Demini, Lucie Kemmat, Alexandre Garlaschelli, Benoit Barrou, Elisabeth Leize-Zal
Acute Safety Study of the Intravenous Injection of a Lyophilized Form of an Extracellular Hemoglobin, M101, in the Rat
Springer Nature - 2026
https://link.springer.com/chapter/10.1007/978-3-032-22656-3_48

Henry Liu, Alan D.Kaye, Jonathan S.Jahr
Blood Sustitutes and Oxygen Biotherapeutics
Springer Nature - 2026
https://link.springer.com/book/10.1007/978-3-032-22656-3

Ugo Lancien, MD, MSc; Pierre-Joachim Mahe, MD; Aline Lepelletier, MD; Elisabeth Leize-Zal, MD; Laurent Lantieri MD, Phd; Pierre Perrot, MD, Phd;
Hydrogel Containing Oxygen Carrier with Hemoglobin from the Marine Worm Arenicola Marina M101in Management of Deep Burns
PRS Global Open 2025 13:e6930 - 2025
https://journals.lww.com/prsgo/fulltext/2025/07000/hydrogel_containing_an_oxygen_carrier_with.9.aspx

Prof Laurent Lantieri MD, Prof Bernard Cholley MD, Prof Cedric Lemogne MD, Romain Guillemain MD, Prof Nicolas Ortonne MD, Prof Philippe Grimbert MD et al.
First human facial retransplantation: 30-month follow-up
The Lancet, Volume 396, Issue 10264, 1758 - 1765-November 28, 2020 - 2020
https://www.thelancet.com/article/S0140673620324387/abstract

Tamer O.Awan, Martin Lhuaire, Laurent Lantieri
Use of HEMHealing, an Oxygenating Dressing in the Treatment of a Full-thickness Burn on the Fingertips
Plastic and Reconstructive Surgery Global Open - 2024
https://pubmed.ncbi.nlm.nih.gov/39175515/

Batool, F., Petit, C., Stutz, C., Özçelik, H., Gegout, P. Y., Benkirane-Jessel, N., Delpy, E., Zal, F., Leize-Zal, E., Huck, O.
M101, a therapeutic oxygen carrier derived from Arenicola marina, decreased Porphyromonas gingivalis-induced hypoxia and improved periodontal healing
J Periodontol. - 2022
https://pubmed.ncbi.nlm.nih.gov/35536914/

Le Meur, Y., Delpy, E., Renard, F., Hauet, T., Badet, L., Rerolle, JP., Thierry, A., Büchler, M., Zal, F., Barrou, B.
HEMO2life® improves renal function independent of cold ischemia time in kidney recipients: A comparison with a large multicenter prospective cohort study
Artificial Organs. - 2021
https://pubmed.ncbi.nlm.nih.gov/34951495/

Asong-Fontem, N., Panisello-Rosello, A., Lopez, A., Imai, K., Zal, F., Delpy, E., Rosello-Catafau, J., Adam, R.
A Novel Oxygen Carrier (M101) Attenuates Ischemia-Reperfusion Injuries during Static Cold Storage in Steatotic Livers
Int. J. Mol. Sci. - 2021
https://pubmed.ncbi.nlm.nih.gov/34445250/

Le Daré, B., Ferron, PJ., Bellamri, N., Ribault, C., Delpy, E., Zal, F., Lagente, V., Gicquel, T.
A therapeutic oxygen carrier isolated from Arenicola marina decreases amanitin-induced hepatotoxicity
Toxicon. - 2021
https://pubmed.ncbi.nlm.nih.gov/34274377/

Batool, F., Delpy, E., Zal, F., Leize-Zal, E., Huck, O.
Therapeutic potential of hemoglobin derived from the marine worm Arenicola marina (M101): a literature review of a breakthrough innovation
Mar Drugs. - 2021
https://pubmed.ncbi.nlm.nih.gov/34210070/