Publications

Hemarina is a biotechnology company with a strong R&D activity. Our teams have a unique know-how, based on fifteen years of fundamental research. The results of our research are the subject of numerous scientific articles published in leading journals.

HEMARINA TECHNOLOGY

Özçelik, H., Batool, F., Corre, M., Garlaschelli, A., Conzatti, G., Stutz, C., Petit, C., Delpy, E., Zal, F., Leize-Zal, E., , Huck, O.
Characterization of a hyaluronic acid-based hydrogel containing an extracellularoxygen carrier (M101) for periodontitis treatment: an in vitro study
Int J Pharm. - 2021
https://pubmed.ncbi.nlm.nih.gov/34144138/

Ali, A., Watanabe, Y., Galasso, M., Watanabe, T., Chen, M., Fan, E., Brochard, L., Ramadan, K., Ribeiro, RVP., Stansfield, W., Gokhale, H., Gazzalle, A., Waddell, T., Liu, M., Keshavjee, S., Cypel, M.
An extracellular oxygen carrier during prolonged pulmonary preservation improves post-transplant lung function
J Heart Lung Transplant. - 2020
https://www.ncbi.nlm.nih.gov/pubmed/32334946

Batool, F., Stutz, C., Petit, C., Benkirane-Jessel, N., Delpy, E., Zal, F., Leize-Zal, E., Huck.
A therapeutic oxygen carrier isolated from Arenicola marina decreased P. gingivalis induced inflammation and tissue destruction.
Sci Rep. - 2020
https://pubmed.ncbi.nlm.nih.gov/32901057/

Le Meur, Y., Morelon, E., Essig, M., Thierry, A., Büchler, M., Drouin, S., Deruelle, C., Badet, L., Pesteil, F., Delpech, P-O., Boutin, J-M., Renard, F., Barrou, B.
First-in-human use of a marine oxygen carrier for organ preservation: a safety and proof-of-principle study.
Am J Transplant. - 2020
https://www.ncbi.nlm.nih.gov/pubmed/32012441

Alix, P., Val-Laillet, D., Turlin, B., Ben Mosbah, I., Burel, A., Bobillier, E., Bendavid, C., Delpy, E., Zal, F., Corlu, A., Boudjema, K.
Adding the oxygen carrier M101 to a cold-storage solution could be an alternative to HOPE for liver graft preservation.
JHEP Rep. - 2020
https://pubmed.ncbi.nlm.nih.gov/32695967/

Lemaire, F., Sigrist, S., Delpy, E., Cherfan, J., Peronet, C., Zal, F., Bouzakri, K., Pinget, M., Maillard, E.
Beneficial effects of the novel marine oxygen carrier M101 during cold preservation of rat and human pancreas.
Journal of Cellular and Molecular Medicine. - 2019
https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.14666

Kaminski, J., Hannaert, P., Kasil,A., Thuillier, R., Leize, E., Delpy, E., Steichen, C., Goujon, J.-M., Zal, F., Hauet, T.
Efficacy of the natural oxygen transporter HEMO2life® in cold preservation in a preclinical porcine model of donation after cardiac death.
Transplant International, official journal of the European Society for Organ Transplantation. - 2019
https://www.ncbi.nlm.nih.gov/pubmed/30924562

Thuillier, R., Delpy, E., Matillon, X., Kaminski J., Kasil, A., Soussi, D., Danion, J., Sauvageon, Y., Rod, X., Donatini, G., Barrou, B., Badet, L., Zal, F., Hauet, T.
Preventing acute kidney injury during transplantation: the application of novel oxygen carriers.
Expert Opinion on Investigational Drugs, 28(7):643-657. - 2019
https://www.ncbi.nlm.nih.gov/pubmed/31165652

Kasil, A., Giraud, S., Couturier, P., Amiri, A., Danion, J., Donatini, G., Matillon, X., Hauet, T., Badet, L.
Individual and combined impact of oxygen and oxygen transporter supplementation during kidney machine preservation in a porcine preclinical kidney transplantation model.
International Journal of Molecular Sciences, 20(8). - 2019
https://www.ncbi.nlm.nih.gov/pubmed/31018558

Mouré, A., Bacou, E., Bosch, S., Jegou, D.,Salama, A., Riochet, D., Gauthier, O., Blancho, G., Soulillou, J.-P., Poncelet, D., Olmos, E., Bach, J.-M., Mosser, M.
Extracellular hemoglobin combined with an O2‐generating material overcomes O2 limitation in the bioartificial pancreas.
Biotechnology and Bioengineering, 116(5):1176-1189. - 2018
https://www.ncbi.nlm.nih.gov/pubmed/30593660